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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

A2780 cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Akt (1) AMPK (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Apoptosis (7) Aurora Kinase (2) Autophagy (1) Bcl-2 Family (1) Caspase (1) CDK (3) DNA Alkylator/Crosslinker (2) EGFR (1) Epigenetic Reader Domain (1) HDAC (2) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (1) MDM-2/p53 (1) Microtubule/Tubulin (1) mTOR (1) NAMPT (3) P-glycoprotein (1) Parasite (1) PARP (1) PI3K (1) PKA (1) PKC (1) Potassium Channel (1) Reactive Oxygen Species (1) Sirtuin (1)
By Research Areas:	Cancer (27) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1)

By Targets:

ADC Cytotoxin (1)

Akt (1)

AMPK (1)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (1)

Apoptosis (7)

Aurora Kinase (2)

Autophagy (1)

Bcl-2 Family (1)

Caspase (1)

CDK (3)

DNA Alkylator/Crosslinker (2)

EGFR (1)

Epigenetic Reader Domain (1)

HDAC (2)

HIF/HIF Prolyl-Hydroxylase (1)

Histone Acetyltransferase (1)

MDM-2/p53 (1)

Microtubule/Tubulin (1)

mTOR (1)

NAMPT (3)

P-glycoprotein (1)

Parasite (1)

PARP (1)

PI3K (1)

PKA (1)

PKC (1)

Potassium Channel (1)

Reactive Oxygen Species (1)

Sirtuin (1)

By Research Areas:

Cancer (27)

Cardiovascular Disease (1)

Infection (1)

Inflammation/Immunology (1)

Metabolic Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: Nuclear Factor of activated T Cells (NFAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7825

Gomisin L1

Others Cancer

Gomisin L1 is a lignan, shows inhibitory effect on cell viability of A2780 and Ishikawa cells, with IC₅₀s of 39.06 μM and 74.16 μM, respectively .

Gomisin L1	Others	Cancer
Gomisin L1 is a lignan, shows inhibitory effect on cell viability of A2780 and Ishikawa cells, with IC₅₀s of 39.06 μM and 74.16 μM, respectively .

HY-146540

GEM-5	HIF/HIF Prolyl-Hydroxylase Apoptosis MDM-2/p53	Cancer
GEM-5 is a gemcitabine-based conjugate containing a HIF-1α inhibitor (YC-1) (IC₅₀=30 nM). GEM-5 can significantly down-regulate the expression of HIF-1α and up-regulate the expression of tumor suppressor p53. GEM-5 induces the apoptosis of A2780 cells and inhibits tumor growth .

HY-141861

Anticancer agent 17

Others Cancer

Anticancer agent 17 displays potent anticancer activities against HeLa and A2780 cells with IC₅₀ values of 0.19 μM and 0.09 μM, respectively.

Anticancer agent 17	Others	Cancer
Anticancer agent 17 displays potent anticancer activities against HeLa and A2780 cells with IC₅₀ values of 0.19 μM and 0.09 μM, respectively.

HY-155506

NAMPT degrader-3	NAMPT	Cancer
NAMPT degrader-3 (compound C5) is a NAMPT degrader, depending on VHL- and proteasome manner. NAMPT degrader-3 displays cytotoxicity and inhibits A2780 cells proliferation .

HY-N2863

Goniothalenol	Others	Cancer
Goniothalenol is a styryl lactone that can be isolated from Goniothalamus griffithii. Goniothalenol exhibits cytatoxic activity against A2780, HCT-8, KB and MCF-7 cell lines .

HY-N10846

Neotriptonoterpene	Others	Others
Neotriptonoterpene, a compound isolated from T. regelii, shows weak cytotoxic activity against A2780, HepG2 and MCF-7 cells with IC₅₀ values of 65.80, 35.45 and 64.80 µM respectively .

HY-N9067

Sanggenofuran B	Others	Cancer
Sanggenofuran B is 2-arylbenzofuran with anti-cancer activity. Sanggenofuran B inhibits A2780 cell line with an IC₅₀ value of 57.1 μM. Sanggenofuran B can be isolated from the root bark of Chinese Morus cathayana .

HY-144337

DNA crosslinker 4 dihydrochloride	DNA Alkylator/Crosslinker	Cancer
DNA crosslinker 4 (dihydrochloride) is a potent DNA minor groove binder. DNA crosslinker 4 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 4 (dihydrochloride) can be used for researching anticancer .

HY-149981

P-gp inhibitor 13	P-glycoprotein	Cancer
P-gp inhibitor 13 is a P-gp inhibitor. P-gp inhibitor 13 can reverse P-glycoprotein-mediated paclitaxel resistance in A2780/T cell. P-gp inhibitor 13 can be used for the research of advanced acute myeloid leukemia .

HY-N9892

Guttiferone G	Sirtuin	Others
Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC₅₀: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC₅₀: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla .

HY-147193

Nampt-IN-10 TFA	NAMPT	Cancer
Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 TFA shows cellular potency to A2780 and CORL23 cells lines with IC₅₀s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs .

HY-147193A

Nampt-IN-10 trihydrochloride	NAMPT	Cancer
Nampt-IN-10 trihydrochloride (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 trihydrochloride shows cellular potency to A2780 and CORL23 cell lines with IC₅₀ values of 5 and 19 nM, respectively. Nampt-IN-10 trihydrochloride can be used as a novel non-antimitotic payload for antibody-drug conjugate (ADC) .

HY-144335

DNA crosslinker 2 dihydrochloride	DNA Alkylator/Crosslinker	Cancer
DNA crosslinker 2 (dihydrochloride) is a potent DNA minor groove binder with DNA binding affinity (ΔT_m) of 1.2 °C. DNA crosslinker 2 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 2 (dihydrochloride) can be used for researching anticancer .

HY-12496

NS-1619 2 Publications Verification	Potassium Channel Apoptosis	Cardiovascular Disease Cancer
NS-1619 is an opener of large conductance Ca ²⁺-activated K ⁺ (BK) channel. NS-1619 is a highly effective relaxant with an EC₅₀ of about 10 – 30 μM in several smooth muscles of blood vessels and other tissues . NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells .

HY-N10268

3-Hydroxyterphenyllin NSC 299113	Apoptosis	Cancer
3-Hydroxyterphenyllin is a metabolite of Aspergillus candidus.3-Hydroxyterphenyllin suppresses proliferation and causes cytotoxicity against A2780/CP70 and OVCAR-3 cells. 3-Hydroxyterphenyllin induces S phase arrest and apoptosis. 3-Hydroxyterphenyllin has the potential for the research of ovarian cancer .

HY-119694

Rotenolone	Others	Cancer
Rotenolone is an antiproliferative agent. Rotenolone shows antiproliferative activity against the ovarian cancer A2780, breast cancer BT-549, prostate cancer DU 145, NSCLC NCI-H460, and colon cancer HCC-2998 cell lines, with IC₅₀s of 0.95, 1.6, 2.7, 2.0, and 2.9 μM, respectively .

HY-10226

JNJ-16241199 R306465	Apoptosis HDAC	Cancer
JNJ-16241199 is an orally active, selective hydroxamate-based histone deacetylase (HDAC) inhibitor, with the IC₅₀ of 3.3 nM and 23 nM for HDAC1 and HDAC8, respectively. JNJ-16241199 induces histone 3 acetylation and strongly increases the expression of p21 ^waf1, ^cip1 in A2780 ovarian carcinoma cells. JNJ-16241199 induces cell apoptosis and shows anticancer activity in a broad spectrum of human malignancies. JNJ-16241199 can be used for cancer study .

HY-143339

CBP/p300-IN-15	Epigenetic Reader Domain Histone Acetyltransferase	Cancer
CBP/p300-IN-15 (compound 13a) is a potent p300/CBP inhibitor, with IC₅₀ values of 2.50 and 28.0 nM, respectively. CBP/p300-IN-15 shows good activity against OVCAR-3 and A2780 cell line, with EC₅₀ values of 0.865 and 2.71 μM, respectively. CBP/p300-IN-15 can be used for ovarian cancer research .

HY-124348

DM-PIT-1 3,5-Dimethyl PIT-1	PI3K	Cancer
DM-PIT-1 is a PIP3/PH (phosphatidylinositol-3,4,5-triphosphate/Pleckstrin) interaction inhibitor . DM-PIT-1 has the potential for the research of ovarian cancer .

HY-145394

CDK7-IN-6	CDK	Cancer
CDK7-IN-6 is a potent and selective cyclin-dependent kinase (CDK7) inhibitor (IC₅₀≤100 nM), extracted from patent WO2019197549 A1, compound 210. CDK7-IN-6 is > 200-fold selective for CDK7 over CDK1, CDK2, and CDK5. CDK7-IN-6 can be used for the research of cancer .

HY-N0281

Daphnetin 2 Publications Verification 7,8-Dihydroxycoumarin	EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species Caspase Bcl-2 Family PARP Parasite	Inflammation/Immunology Cancer
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1ß, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .

HY-12003

SNS-314 mesylate 2 Publications Verification	Aurora Kinase	Cancer
SNS-314 mesylate is a potent and selective aurora kinase inhibitor with IC₅₀s of 9, 31, and 6 nM for aurora A, B and C, respectively .

HY-N3446

IVHD-valtrate	Apoptosis	Cancer
IVHD-valtrate, an active Valeriana jatamansi derivative, is against human ovarian cancer cells in vitro and in vivo. IVHD-valtrate induces cancer cells apoptosis and arrests the ovarian cancer cells in the G2/M phase. IVHD-valtrate has the potential to be a novel chemotherapeutic agent for the human ovarian cancer research .

HY-108344

SNS-314

Aurora Kinase Cancer

SNS-314 is a potent and selective aurora kinase inhibitor with IC₅₀s of 9, 31, and 6 nM for aurora A, B and C, respectively .

SNS-314	Aurora Kinase	Cancer
SNS-314 is a potent and selective aurora kinase inhibitor with IC₅₀s of 9, 31, and 6 nM for aurora A, B and C, respectively .

HY-153917

CRT0063465	Others	Metabolic Disease Cancer
CRT0063465 is a Ligand of HumanPGK1andStress Sensor DJ1, with theK_dof 24 μM ofPGK1. CRT0063465 modulates the shelterin complex composition and telomere Length .

HY-15275

BMS-265246	CDK Angiotensin-converting Enzyme (ACE)	Infection Cancer
BMS-265246 is a potent and selective cyclin-dependent kinase CDK1 and CDK2 inhibitor, with IC₅₀ values of 6 and 9 nM, respectively. BMS-265246 inhibits CHI3L1 (chitinase 3-like-1) stimulation of ACE2 (angiotensin converting enzyme 2) and SPP (viral spike protein priming proteases). BMS-265246 can be used for ovarian cancer and COVID-19 research .

HY-P2228

Chlamydocin	HDAC Apoptosis	Cancer
Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC₅₀ of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3 .

HY-145402

CDK7-IN-7

CDK Cancer

CDK7-IN-7 is a potent and selective CDK7 kinase inhibitor with an IC₅₀ of <50 nM (Patent CN112661745A, compound T-01) .

CDK7-IN-7	CDK	Cancer
CDK7-IN-7 is a potent and selective CDK7 kinase inhibitor with an IC₅₀ of <50 nM (Patent CN112661745A, compound T-01) .

HY-15995

Tubulysin A 1 Publications Verification TubA	ADC Cytotoxin Antibiotic Microtubule/Tubulin	Cancer
Tubulysin A (TubA) is an anticancer and antiangiogenic agent with anti-microtubule, anti-mitosis and anti-proliferative activity against a variety of cancer cells with IC₅₀ values in the pmol range. It can induce apoptosis of cancer cells and has no effect on normal cells. Tubulysins are a group of potent cytotoxins consisting of nine members (A-I). Tubulysin A can synthesize ADC as ADC Cytotoxin< b>ADC Cytotoxin .

Chlamydocin	HDAC Apoptosis	Cancer
Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC₅₀ of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3 .

Gomisin L1	Triterpenes Structural Classification Terpenoids Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	Others
Gomisin L1 is a lignan, shows inhibitory effect on cell viability of A2780 and Ishikawa cells, with IC₅₀s of 39.06 μM and 74.16 μM, respectively .

Goniothalenol	Goniothalamus calvicarpus Craib Structural Classification Natural Products Source classification Plants Annonaceae	Others
Goniothalenol is a styryl lactone that can be isolated from Goniothalamus griffithii. Goniothalenol exhibits cytatoxic activity against A2780, HCT-8, KB and MCF-7 cell lines .

Neotriptonoterpene	Structural Classification Terpenoids Source classification Celastraceae Diterpenoids Plants Tripterygium wilfordii Hook. f.	Others
Neotriptonoterpene, a compound isolated from T. regelii, shows weak cytotoxic activity against A2780, HepG2 and MCF-7 cells with IC₅₀ values of 65.80, 35.45 and 64.80 µM respectively .

Sanggenofuran B	Structural Classification Source classification Phenols Polyphenols Plants Moraceae Morus cathayana Hemsl.	Others
Sanggenofuran B is 2-arylbenzofuran with anti-cancer activity. Sanggenofuran B inhibits A2780 cell line with an IC₅₀ value of 57.1 μM. Sanggenofuran B can be isolated from the root bark of Chinese Morus cathayana .

Guttiferone G	Structural Classification Garcinia xanthochymus Hook. f. ex T. Anders. Source classification Guttiferae Phenols Polyphenols Plants	Sirtuin
Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC₅₀: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC₅₀: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla .

3-Hydroxyterphenyllin NSC 299113	Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields Cancer	Apoptosis
3-Hydroxyterphenyllin is a metabolite of Aspergillus candidus.3-Hydroxyterphenyllin suppresses proliferation and causes cytotoxicity against A2780/CP70 and OVCAR-3 cells. 3-Hydroxyterphenyllin induces S phase arrest and apoptosis. 3-Hydroxyterphenyllin has the potential for the research of ovarian cancer .

Daphnetin 2 Publications Verification 7,8-Dihydroxycoumarin	Classification of Application Fields Daphne Thymelaeaceae Source classification Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species Caspase Bcl-2 Family PARP Parasite
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1ß, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .

IVHD-valtrate	Natural Products Classification of Application Fields Source classification Valeriana officinalis Linn. Plants Valerianaceae Disease Research Fields Cancer	Apoptosis
IVHD-valtrate, an active Valeriana jatamansi derivative, is against human ovarian cancer cells in vitro and in vivo. IVHD-valtrate induces cancer cells apoptosis and arrests the ovarian cancer cells in the G2/M phase. IVHD-valtrate has the potential to be a novel chemotherapeutic agent for the human ovarian cancer research .

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